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发布时间:2018-03-22 16:36:39  本文被阅次数: 我要打印 字号:

赵杰

赵杰,男,教授,博士研究生导师。大连医科大学副校长,神经退行性疾病药物研发国家地方联合工程中心主任、辽宁省防治老年神经退行性病天然产物工程技术研究中心主任、辽宁省抗老年神经退行性疾病天然产物工程实验室主任。国务院特殊津贴获得者,辽宁省特聘教授,大连市优秀专家。长期从事癫痫、神经退行性疾病的发病机制和防治策略研究,多次获国家自然科学基金资助并获得国家科技部新药创制重大专项课题。研究成果获中华医学科技三等奖1项,辽宁省政府科技进步二等奖6项、三等奖2项,国内外发表论文百余篇。
学习经历:
1987/09 - 1990/07,神经病学硕士,大连医科大学
1982/09 - 1987/07,临床医学学士,哈尔滨医科大学
工作经历:
2000/08 - 至今,  教授、博士生导师,大连医科大学
1995/08 - 2000/07,副教授,大连医科大学属第一医院
1990/07 - 1995/07,主治医师,大连医科大学属第一医院
研究方向:
神经系统疾病发病机理和防治策略研究
主要学术任职:
第四届全国高等学校医药学成人学历教育规划教材评审委员会主任委员
全国高等卫生职业教育护理类专业规划教材第四届评审委员会常务委员
中国医药教育协会整合医学教育分会常务理事
辽宁省医学会常务理事
Neuroscience Bulletin杂志常务理事
承担的国家级项目(近5年):
1.国家科技部新药创制重大专项(2018ZX09301028-001),抗难治性癫痫I类新药蝎毒耐热肽的研发,400万,2018.01-220.12,主持人
2.国家自然科学基金面上项目(81671061),Retromer蛋白转运体在蝎毒耐热肽抗阿尔茨海默病机制中的作用,2017.01-2020.12,52万元,主持。
3.国家自然科学基金面上项目(81371437),蝎源抗难治性癫痫肽调控海马硬化可塑性改变的神经发生机制,2014/01-2017/12,65万元,主持。
4.辽宁省科技厅科技计划项目(2011226006),神经保护药物蝎毒神经元营养活性肽的临床前研究,2012/01-2014/12,50万元、主持。
5.辽宁省特聘教授,2013-2015,神经科学,100万。
代表性论文(近5年):
1.Chen JJ, Zhao B, Zhao J*, Li S*. Potential roles of exosomal microRNAs as diagnostic biomarkers and therapeutic application in Alzheimer’s disease. Neural Plasticity. 2017; 2017:7027380. doi: 10.1155/2017/7027380. Epub 2017 Jul 9.
2.Lan YL#, Zhao J#, Ma TH*, Li S*. The potential roles of aquaporin 4 in Alzheimer's disease. Mol Neurobiol. 2016 Oct; 53(8): 5300-9. doi: 10.1007/ s12035-015-9446-1.
3.Zhang XG#, Wang X #, Zhou TT, Wu XF, PengY, Zhang WQ, Zhao J*, Li S*, Scorpion Venom Heat-Resistant Peptide Protects Transgenic Caenorhabditis elegans from β-Amyloid Toxicity. Front Pharmacol. 2016 Jul 26; 7: 227. doi: 10.3389/ fphar.2016.00227. eCollection 2016.
4.Chen JJ, Wang T, An CD, Jiang CY, Zhao J*, Li S*. Brain-derived neurotrophic factor: a mediator of inflammation-associated. Rev Neurosci. 2016 Dec 1;27(8):793-811. doi: 10.1515/revneuro-2016-0017.
5.Lan YL#, Zou S#, Chen JJ, Zhao J*, Li S*. The neuroprotective effect of the association of aquaporin-4/glutamate transporter 1 (AQP4/GLT-1) against Alzheimer’s disease. Neural Plasticity. 2016, Article ID 4626593, 8 pages http://dx.doi.org/ 10.1155 /2016/ 4626593.
6.Lan YL#, Zhao J#, Ma TH*, Li S*. The research update on the potential roles of aquaporin 4 in neuroinflammation. Acta Neurol Belg, 2016 Jun;116(2): 127-34
7.Zhou TT#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease. Int Immunopharmacol. 2015 Nov 5. pii: S1567-5769(15) 30165 -X. doi: 10.1016/j.intimp.2015.10.032.
8.Zhou T#, Zu G#, Zhang X, Wang X, Li S, Gong X, Liang Z*, Zhao J*. Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease. Neuropharmacology. 2015 Oct 23; 101: 480-489. doi: 10.1016/j.neuropharm. 2015.10.024.
9.Lan YL#, Zhao J#, Ma TH*, Li S*. The great significance of research into the physiological relevance between AQP4 and vasopressin for studying Alzheimer's disease. J Alzheimers Dis Parkinsonism 5: 192. doi:10.4172/2161- 0460.1000192
10.Cao Z, Wu XF, Peng Y, Zhang R, Li N, Yang JY, Zhang SQ, Zhang WQ, Zhao J*,Li S*. Scorpion Venom Heat-Resistant Peptide Attenuates Glial Fibrillary Acidic Protein Expression via c-Jun/AP-1. Cell Mol Neurobiol. 2015 Nov; 35(8): 1073-9. doi: 10.1007/s10571-015-0215-5. Epub 2015 Jul 2.
11.Yang JY*, Yang G, Ren J, Zhao J*, Li S*. Caffeine suppresses GABA receptor-mediated current of rat primary sensory neurons via inhibiting intracellular phosphodiesterase. Neurophysiology,April 2015, Volume 47, Issue 2, pp 108-114
12.Lan YL, Zhao J*, Li S*. Update on the Neuroprotective Effect of Estrogen Receptor Alpha against Alzheimer ’s disease. J Alzheimer’s Dis. 2015; 43(4): 1137-48.
13.Lan YL, Zhao J*, Li S. Update on the neuroprotective effect of estrogen receptor alpha against Alzheimer's disease. J Alzheimers Dis. 2015; 43 (4): 1137-48.
14.Wang T, Wang SW, Zhang Y, Wu XF, Peng Y, Cao Z, Ge BY, Wang X, Wu Q, Lin JT, Zhang WQ, Li S, Zhao J*. Scorpion venom heat-resistant peptide (SVHRP) enhances neurogenesis and neurite outgrowth of immature neurons in adult mice by up-regulating brain-derived neurotrophic factor (BDNF). PLoS One. 2014; 9(10): e109977.
15.Wang T, Xia YL, Zhang SL, Gao LJ, Xie ZZ, Yang YZ, Zhao J*. The impact of hypertension on the electromechanical properties and outcome of catheter ablation in atrial fibrillation patients. J Thorac Dis. 2014; 6(7): 913-20.
16.Yin SM, Zhao D, Yu DQ, Li SL, An D, Peng Y, Xu H, Sun YP, Wang DM, Zhao J*, Zhang WQ. Neuroprotection by scorpion venom heat resistant peptide in 6-hydroxydopamine rat model of early-stage Parkinson's disease. Sheng Li Xue Bao. 2014;66(6):658-66.
17.Lan YL, Zhao J*, Li S. Estrogen receptors' neuroprotective effect against glutamate-induced neurotoxicity. Neurol Sci. 2014;35(11):1657-62.
18.Li li Guan, Haiyan Feng, Dezheng Gong, Xu Zhao, Li Cai, Qiong Wu, Bo Yuan, Mei Yang, Jie Zhao*, Yuan Zou.  Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. Experimental Gerontology. 2013; 48(12): 1387-94.
19.Wang ZC, Zhao J*, Li S. Dysregulation of Synaptic and Extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β. Neurosci Bull. 2013; 29(6): 752-760.
20.Y. Sun, X. Cui, Sh. Yin, D. Yu, Sh. Li, W. Zhang, and J. Zhao*. Effects of Scorpion Venom Heat-Resistant Protein on Seizure Behavior and Expression of Proenkephalin in Rats with Kainate-Induced Epilepsy. Neurophysiology. 2013; 45(4): 319-322.
科研获奖(近5年):
1.赵杰(2/7),钠通道亚型Nav1.6与阿尔茨海默病发病机制相关性的基础与临床研究, 辽宁省科技进步,三等奖,2015,证书编号2015J-3-095-2
2.赵杰(1/9),中药蝎毒治疗难治性癫痫的基础与临床研究,辽宁省政府,辽宁省科学技术奖,二等奖,2013,证书编号:2013J-2-58-01。
专利
1.2016年申请一种耐热合成肽及其用途,专利号:ZL2016 1 0645111.7,证书号:2605457 赵杰 李韶 张万琴
联系方式:
Email:dlzhaoj@163.comzhaoj@dlmedu.edu.cn
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